Effect of Low vs. High Intensity Exercise Training on Biomarkers of Inflammation and Endothelial Dysfunction — PubMed


Tenório TRS, Balagopal PB, Andersen LB, Ritti-Dias RM, Hill JO, Lofrano-Prado MC, Prado WL.


To investigate the effects of a low vs. high intensity aerobic training on biomarkers of inflammation and endothelial dysfunction in adolescents with obesity.


Sixty-two adolescents with obesity (age: 15±14 years, BMI: 34.87±4.22 kg.m-2) were randomized to receive either a high intensity training (HIT, n=31) or a low intensity training (LIT, n=31) for 24 weeks. All participants also received nutritional, psychological and clinical counseling. Leptin, total and subtype leukocyte counts, tumor necrosis factor alpha (TNF-α), interleukin-6, myeloperoxidase, soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were obtained at baseline and after 24 weeks.


HIT reduced neutrophils (from 4.4 ± 1.9 to 3.6 ± 1.3 μL-1 x103; p= 0.01) and monocytes (from 7.2 ± 2.5 to 5.2 ± 1.8 μL-1 x102; p< 0.01), but LIT increased neutrophils (from 4.5 ± 1.7 to 5.2 ± 3.3 μL-1 x103; p= 0.01). While TNF-α increased in LIT (from 13.3 (7.5) to 17.7 (10.8) pg.mL-1; p= 0.01), it decreased in HIT (from 12.4 (7.5) to 11.3 (6.2) pg.mL-1; p= 0.01). No changes in leucocyte counts, sICAM-1, sVCAM-1 and homeostasis assessment model for insulin resistance were observed.


Both HIT and LIT improved the inflammatory profile. The study, however, indicated that the number of biomarkers and the magnitude of changes were higher in the HIT compared to LIT.


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